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May 5, 2004

Safety of Newer Antiepileptic Drugs

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(17):2074. doi:10.1001/jama.291.17.2074-a

To the Editor: Although Drs LaRoche and Helmers1 discussed many of the important safety issues for new antiepileptic drugs in their Scientific Review article, additional safety issues have arisen with topiramate and zonisamide since their initial approval. Some of these safety issues may be related to the ability of these drugs to inhibit the enzyme carbonic anhydrase.

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