Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
In Reply: In response to Dr Aguirre and colleagues,
we have analyzed the proportion of patients taking aspirin or other antiplatelet
agents in the 2 treatment groups. As would be expected from randomization
of a large number of patients, there was no imbalance: 49.85% of those in
the high-dose group vs 50.15% of those in the low-dose group were taking these
medications at baseline (P = .71), and this did not
change during the course of the study.
Spence JD, Toole JF, Chambless LE, Wang C, Stampfer M, Pettigrew LC, Howard VJ, Sides EG. Vitamin Supplementation and Risk of Stroke—Reply. JAMA. 2004;291(18):2191-2192. doi:10.1001/jama.291.18.2191-c