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May 26, 2004

Iron Stores as a Risk Factor for Diabetes in Women

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(20):2428-2429. doi:10.1001/jama.291.20.2428-a

To the Editor: Dr Jiang and colleagues1 reported that higher iron stores are an independent risk factor for type 2 diabetes in healthy women. I am concerned that the cases had higher serum ferritin levels at the onset, and differed from controls in other important respects. Compared with controls, cases were more likely at baseline to have a family history of diabetes, an increased body mass index, less physical activity, higher levels of C-reactive protein, and substantially higher levels of insulin and hemoglobin A1c (mean, 6.4%).

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