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May 26, 2004

Reteplase in Acute Myocardial Infarction

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(20):2429-2430. doi:10.1001/jama.291.20.2429-c

To the Editor: Dr Kastrati and colleagues1 reported that among patients with acute myocardial infarction who were referred for percutaneous interventions, early administration of reteplase plus abciximab does not lead to a reduction of infarct size compared with abciximab alone. However, because the trial, which was conducted in Germany, used intravenous 500-mg aspirin as part of the initial treatment, the results may not be applicable to patients in the United States, where aspirin is only available in an oral form.

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