Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
In Reply: In response to Dr Busti and colleagues,
we reviewed the drugs received by patients before and after hospital admission
(Table 1). Based on these data,
we find no evidence of bias generated by concomitant drug therapy. However,
we agree that the high initial dose of aspirin and the broad use of highly
effective drugs, such as β-blockers, angiotensin-converting enzyme inhibitors,
and statins, in our trial should be taken into account before extrapolating
our findings to other settings.
Kastrati A, Schömig A. Reteplase in Acute Myocardial Infarction—Reply. JAMA. 2004;291(20):2429-2430. doi:10.1001/jama.291.20.2430-a