The Centers for Disease Control and Prevention (CDC) is recommending
that fluoroquinolones—ciprofloxacin, ofloxacin, and levofloxacin—no
longer be used as first-line treatment for gonorrhea in gay and bisexual men.
The recommendation was made after preliminary data from a CDC study showed
that drug-resistant gonorrhea cases increased significantly in the United
States in 2003, particularly among men who have sex with men.
Stephenson J. Rise in Drug-Resistant Gonorrhea Cases. JAMA. 2004;291(20):2420. doi:10.1001/jama.291.20.2420