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June 9, 2004

Use of Antibiotics and Risk of Cancer—Reply

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(22):2699. doi:10.1001/jama.291.22.2700-b

In Reply: Each of these letters expresses concern that the association of antibiotic use with increased risk of breast cancer may be confounded by patient characteristics. As we stated in our article, we agree with the need for a thorough exploration of confounding as a possible explanation of the findings. We made every effort to obtain information on pertinent characteristics and to examine the possibility of confounding with the available data. We also stated that information was incomplete on several patient characteristics and not available on other characteristics, and this may have limited our ability to detect and control confounding.

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