Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
In Reply: Each of these letters expresses concern
that the association of antibiotic use with increased risk of breast cancer
may be confounded by patient characteristics. As we stated in our article,
we agree with the need for a thorough exploration of confounding as a possible
explanation of the findings. We made every effort to obtain information on
pertinent characteristics and to examine the possibility of confounding with
the available data. We also stated that information was incomplete on several
patient characteristics and not available on other characteristics, and this
may have limited our ability to detect and control confounding.
Velicer CM, Heckbert SR, Potter JD, Taplin SH. Use of Antibiotics and Risk of Cancer—Reply. JAMA. 2004;291(22):2699. doi:10.1001/jama.291.22.2700-b