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Letters
June 9, 2004

Antiphospholipid Antibodies and Risk for Recurrent Vascular Events

Author Affiliations
 

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(22):2701. doi:10.1001/jama.291.22.2701-b

To the Editor: We have several concerns about the study of Dr Levine and colleagues.1 First, the high proportion of patients with aPL (41%) raises questions about the specificity of the tests they used. Second, the average age of the patients was significantly higher than that of those in most prior studies of antiphospholipid syndrome. Third, the authors achieved a relatively low mean international normalized ratio (INR) among the patients in the high-intensity group.

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