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June 9, 2004

Soluble RANKL and Risk of Nontraumatic Fracture—Reply

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(22):2703. doi:10.1001/jama.291.22.2703-b

In Reply: The assay for soluble free RANKL has been validated according to usual standards,1 is commercially available, and is commonly used.13 Main characteristics including lower detection limit and interassay as well as intra-assay coefficients of variation are provided.1,4 Mean serum levels of RANKL are very similar among different cohorts.1,4 RANKL levels emerged as stable over a 5-year period and correlations between RANKL levels measured from 1990 and 1995 blood samples and between 1990 and 2000 were high, at 0.63 and 0.36 pmol/L, respectively. Figure 2 in our study was based on all individuals.

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