Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Dr Stephenson and colleagues1 reported a 45% 4-year progression-free probability
of isolated biochemical recurrence after radical prostatectomy at a median
follow-up of 45-months following salvage radiotherapy. Although we concur
with the authors that salvage radiotherapy may alter the natural history of
prostate cancer in many men with isolated recurrence of prostate-specific
antigen (PSA), we disagree with Dr Anscher's conclusion, in his accompanying
Editorial,2 that all men with positive surgical
margins should receive adjuvant therapy.
Ward JF, Blute ML. Use and Timing of Radiotherapy in High-Risk Prostate Cancer. JAMA. 2004;291(23):2817. doi:10.1001/jama.291.23.2817-a