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Letters
June 16, 2004

Use and Timing of Radiotherapy in High-Risk Prostate Cancer

Author Affiliations
 

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(23):2817. doi:10.1001/jama.291.23.2817-a

To the Editor: Dr Stephenson and colleagues1 reported a 45% 4-year progression-free probability of isolated biochemical recurrence after radical prostatectomy at a median follow-up of 45-months following salvage radiotherapy. Although we concur with the authors that salvage radiotherapy may alter the natural history of prostate cancer in many men with isolated recurrence of prostate-specific antigen (PSA), we disagree with Dr Anscher's conclusion, in his accompanying Editorial,2 that all men with positive surgical margins should receive adjuvant therapy.

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