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June 16, 2004

Use and Timing of Radiotherapy in High-Risk Prostate Cancer—Reply

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2004;291(23):2817. doi:10.1001/jama.291.23.2818-a

In Reply: I agree with Drs Ward and Blute that there are few randomized trials dealing with any aspect of the diagnosis and management of this common disease. Thus, physicians often have no recourse but to refer to retrospective data and basic principles of oncology when recommending treatments to patients with prostate cancer. One such principle is that positive surgical margins require additional treatment to prevent the inevitable recurrence of disease.

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