Medical News and Perspectives
June 16, 2004

With RNA Interference, Silence Is Golden

JAMA. 2004;291(23):2803-2804. doi:10.1001/jama.291.23.2803

Clinical researchers are constantly trying to convince cells within the body to change their ways. In some conditions, such as cancer, they want to stop cells from growing; in others, such as Parkinson disease, they want to keep cells from dying.

Because gene expression controls how a cell looks and acts, a logical approach to manipulating a cell's behavior would be to turn genes on or off. But effectively targeting a particular gene within a chromosome is a laborious process, and it is not even currently feasible for some genes. So researchers are studying a variety of other strategies they hope will achieve the same ends.

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