June 23/30, 2004

Sex Differences and Genetic Associations With Myocardial Infarction

Author Affiliations

Author Affiliations: NHLBI Framingham Heart Study, Framingham, Mass; Cardiology Division, Massachusetts General Hospital, Boston; and Broad Institute of Harvard and MIT, Cambridge, Mass.

JAMA. 2004;291(24):3008-3010. doi:10.1001/jama.291.24.3008

Myocardial infarction (MI) and related atherosclerotic cardiovascular disease (CVD) are the leading causes of death in men and women.1 Although much is known regarding risk factors for MI, many questions remain unanswered in the prevention of MI, including what specific genetic variants underlie susceptibility to MI and why there appears to be a protective advantage against MI in women compared with men. The article by Schuit et al2 in this issue of JAMA helps address some of these questions but raises others.

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