Author Affiliations: NHLBI Framingham Heart Study, Framingham, Mass; Cardiology Division, Massachusetts General Hospital, Boston; and Broad Institute of Harvard and MIT, Cambridge, Mass.
Myocardial infarction (MI) and related atherosclerotic cardiovascular
disease (CVD) are the leading causes of death in men and women.1 Although
much is known regarding risk factors for MI, many questions remain unanswered
in the prevention of MI, including what specific genetic variants underlie
susceptibility to MI and why there appears to be a protective advantage against
MI in women compared with men. The article by Schuit et al2 in
this issue of JAMA helps address some of these questions but raises others.
Newton-Cheh C, O'Donnell CJ. Sex Differences and Genetic Associations With Myocardial Infarction. JAMA. 2004;291(24):3008-3010. doi:10.1001/jama.291.24.3008