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July 7, 2004

Adiponectin and Risk of Coronary Heart Disease

JAMA. 2004;292(1):40. doi:10.1001/jama.292.1.40-a

To the Editor: Dr Pischon and colleagues1 reported an inverse association between adiponectin levels and risk of myocardial infarction and death from coronary heart disease. Although the authors measured total levels of adiponectin, several studies have suggested that only the fraction bound to high-molecular-weight complexes is related to various indicators of insulin sensitivity.24