To the Editor: Dr Pischon and colleagues1 reported an inverse association between adiponectin
levels and risk of myocardial infarction and death from coronary heart disease.
Although the authors measured total levels of adiponectin, several studies
have suggested that only the fraction bound to high-molecular-weight complexes
is related to various indicators of insulin sensitivity.2- 4
Schlegel A. Adiponectin and Risk of Coronary Heart Disease. JAMA. 2004;292(1):40. doi:10.1001/jama.292.1.40-a