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July 7, 2004

Inflammation and Age-Related Macular Degeneration—Reply

JAMA. 2004;292(1):43. doi:10.1001/jama.292.1.43-b

In Reply: We reported the first association between high-sensitivity C-reactive protein levels and age-related macular degeneration. As we stated, the role of inflammation is biologically plausible based on previous research, including the association of neovascularization with inflammatory eye diseases. We also noted that there is an evolving hypothesis that inflammation is associated with the pathogenesis of AMD, and that our clinical results lend support to that potential mechanism. Furthermore, we recognized that additional epidemiologic as well as basic research is needed to sort out whether the association with inflammation is primary (ie, causal or predictive) or secondary (ie, a reaction to other stimuli).