Letters Section Editor: Robert M. Golub,
MD, Senior Editor.
To the Editor: Dr Hull and colleagues1 found that radiation therapy was associated with
an increased incidence of atherosclerotic events among patients with Hodgkin
lymphoma. Many of these patients, however, were treated during a time when
splenectomy was a common part of staging for Hodgkin disease. Splenectomy
is a risk factor for myocardial infarction2- 4 and
other atherosclerotic events.3 I believe
that the authors should have accounted for splenectomy status in their analysis.
Schilling RF. Radiation Therapy and Risk of Cardiovascular Disease. JAMA. 2004;292(4):433-434. doi:10.1001/jama.292.4.433-b