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August 11, 2004

Effects of Estrogen-Only Treatment in Postmenopausal Women

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(6):683. doi:10.1001/jama.292.6.684-a

To the Editor: The Women's Health Initiative Steering Committee1 states that its findings on the relationship between breast cancer and use of estrogen-only hormone therapy are contrary to the preponderance of observational study results, including those from the recent Million Women Study. However, no consideration was given to the variation in the prevalence of obesity across study populations, and obese women have considerably lower relative risks than thinner women for hormone therapy–related breast cancer.2,3

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