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Letters
August 11, 2004

Effects of Estrogen-Only Treatment in Postmenopausal Women

Author Affiliations
 

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(6):683. doi:10.1001/jama.292.6.684-c

To the Editor: The WHI investigators found that use of estrogen alone was associated with a lower risk of breast cancer,1 while estrogen-plus-progestin was associated with an increased risk.2 We found similar results in our large cohort study of 374 465 postmenopausal women conducted between 1996 and 2000 in community-based mammography practices.3 We found the risk of breast cancer among women using estrogen alone for less than 5 years, compared with women not using hormone therapy, was decreased 14% (95% CI, –29% to 3%) with 51 estrogen-only breast cancer cases. We found the risk of breast cancer among women using estrogen alone for more than 5 years, compared with women not using hormone therapy, was decreased 8% (95% CI, –16% to 0%) with 272 estrogen-only breast cancer cases. We also found the risk of breast cancer was increased 49% (95% CI, 36%-63%) among women using estrogen-plus-progestin for 5 years or more, compared with nonusers, with 298 estrogen-plus-progestin cancer cases.

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