Letters Section Editor: Robert M. Golub,
MD, Senior Editor.
In Reply: Regarding Dr Kuhl's concern about
the early stopping of our trial, we regret that the WHI cannot provide more
definitive data on the effects of CEE on breast cancer including longer-term
use, or on potential benefits for CHD, since these questions provided the
primary motivation for our trial. It remains possible that CEE may have reduced
CHD rates in women aged 50 to 59 years at enrollment, but our data cannot
resolve this issue. We disagree with Kuhl's concern about the relevance of
our sample, however, as the women in WHI represent the very women for whom
CHD primary prevention would be considered.
Anderson GL. Effects of Estrogen-Only Treatment in Postmenopausal Women—Reply. JAMA. 2004;292(6):683. doi:10.1001/jama.292.6.685-c