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September 1, 2004

Antepartum Dental Radiography and Low Birth Weight

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(9):1019. doi:10.1001/jama.292.9.1019-c

To the Editor: We are concerned that by performing a large number of statistical tests on the same data set, Dr Hujoel and colleagues1 underestimated the type I error rate. Three infant outcomes (preterm, LBW, and term LBW) were evaluated for each of 17 dental procedure characteristics, resulting in 51 possible effects. When we applied the Bonferroni correction for the evaluation of 51 repeated measurements we determined that a P value of less than .00009 would be required to achieve statistical significance.

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