Books, Journals, New Media Section Editor: Harriet
S. Meyer, MD, Contributing Editor, JAMA; David H. Morse, MS, University
of Southern California, Norris Medical Library, Journal Review Editor.
Making Mice is an institutional history of
the world's premier mouse merchant, the Jackson Laboratory of Bar Harbor,
Maine. It traces the invention, promotion, and changing uses of inbred laboratory
mice by following the career of their impresario, the geneticist and mouse-breeder
Clarence Cook Little (1888-1971).
Somewhat like Charles Darwin, who maintained close ties with pigeon
fanciers and pondered the effects of breeding on bird color, morphology, and
behavior, Little and his Harvard College mentor William E. Castle began their
mice colonies with the stocks of fanciers and studied coat variations. Little's
professional trajectory included time at the Cold Spring Harbor laboratory
and stints as president of the universities of Maine and Michigan. Never one
to shy away from controversy, he advocated human birth control and engaged
in eugenics debates.
Osborne MA. Mice. JAMA. 2004;292(12):1497. doi:10.1001/jama.292.12.1497-a