Author Affiliations: University of Ottawa Centre
for Transfusion and Critical Care Research and Clinical Epidemiology Program,
Ottawa Health Research Institute, Ottawa, Ontario.
Over the last half-century, it has become well recognized that patients
with cardiovascular diseases and, more specifically, ischemic heart disease
may be adversely affected by anemia. This is because the myocardium consumes
or extracts 60% to 75% of all oxygen delivered to the coronary circulation.1- 3 Such an elevated extraction
of oxygen, termed extraction ratio, is unique to the coronary circulation.
As a result, oxygen delivery to the myocardium can be augmented only by increasing
blood flow or oxygen content.1
Hébert PC, Fergusson DA. Do Transfusions Get to the Heart of the Matter?. JAMA. 2004;292(13):1610-1612. doi:10.1001/jama.292.13.1610