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October 6, 2004

Natural History of Early Localized Prostate Cancer

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(13):1549-1550. doi:10.1001/jama.292.13.1549-b

To the Editor: Dr Johansson and colleagues1 contribute valuable information on the natural history of prostate cancer. However, in my opinion their conclusions are not warranted. The radical treatments available for this disease involve a significant risk of adverse effects and, consequently, often result in a decreased quality of life for patients. Due to widespread use of prostate-specific antigen testing, overdiagnosis and overtreatment have become significant problems2,3 in both treatment of indolent tumors and in radical treatment.

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