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October 13, 2004

Estrogen Receptor α Polymorphisms and the Risk of Myocardial Infarction

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(14):1683-1684. doi:10.1001/jama.292.14.1683-a

To the Editor: Dr Schuit and colleagues1 demonstrated a significant association between estrogen receptor α gene (ESR1) polymorphisms and increased risk of myocardial infarction (MI) in postmenopausal women but not in men. Since Mattila et al2 first found an association between poor oral health and risk of MI in men, several studies have found such an association in women as well.3 We have reported a significant association between ESR1 polymorphisms and tooth loss in postmenopausal women.4

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