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October 13, 2004

Premutation Alleles Associated With Parkinson Disease and Essential Tremor

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(14):1681-1686. doi:10.1001/jama.292.14.1685-b

To the Editor: There is evidence that older male carriers of premutation alleles (55-200 CGG repeats) of the fragile X mental retardation 1 (FMR1) gene are at high risk of developing the fragile X–associated tremor/ataxia syndrome1 and spinocerebellar ataxia.2 Since the phenotypes associated with these disorders overlap with those of Parkinson disease (PD) and essential tremor, we sought to determine the prevalence of FMR1 premutation alleles in men with these movement disorders.

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