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October 20, 2004

Chlorthalidone vs Other Low-Dose Diuretics

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(15):1816-1817. doi:10.1001/jama.292.15.1816-c

To the Editor: Dr Psaty and colleagues1 compared the results of 2 meta-analyses, each of which looked individually at the efficacy of either chlorthalidone or other low-dose diuretics compared with placebo, not with each other. Based on small efficacy differences, Psaty et al concluded that “major health outcomes for chlorthalidone and other thiazide-like drugs appear to be similar.” We believe that it is necessary to directly compare treatments to reach conclusions about differences between them.

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