Letters Section Editor: Robert M. Golub,
MD, Senior Editor.
To the Editor: Dr Psaty and colleagues1 compared the results of 2 meta-analyses, each of which
looked individually at the efficacy of either chlorthalidone or other low-dose
diuretics compared with placebo, not with each other. Based on small efficacy
differences, Psaty et al concluded that “major health outcomes for chlorthalidone
and other thiazide-like drugs appear to be similar.” We believe that
it is necessary to directly compare treatments to reach conclusions about
differences between them.
Choi KL, Chua D, Elliott WJ. Chlorthalidone vs Other Low-Dose Diuretics. JAMA. 2004;292(15):1816-1817. doi:10.1001/jama.292.15.1816-c