Letters Section Editor: Robert M. Golub,
MD, Senior Editor.
In Reply: In response to Dr Pedrini and colleagues,
we did not design our study to evaluate the important question of the duration
of antithrombin therapy. Our protocol suggested a minimum duration of treatment
with unfractionated or low-molecular-weight heparin of 48 hours, but treatment
duration could be shortened for those undergoing early percutaneous intervention,
with heparin discontinuation permitted 12 hours after intervention. Maximal
duration for study-provided medications was limited to 120 hours by protocol.
Although not based on data from randomized controlled trials, this strategy
is consistent with American College of Cardiology/American Heart Association
Blazing MA. Enoxaparin vs Unfractionated Heparin in Acute Coronary Syndrome—Reply. JAMA. 2004;292(16):1952-1953. doi:10.1001/jama.292.16.1953-a