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October 27, 2004

Emphysematous Cystitis and Renal Stones in Cystic Fibrosis

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(16):1951-1954. doi:10.1001/jama.292.16.1953-b

To the Editor: First reported by E. L. Keyes in 1882,1 emphysematous cystitis is a rare complication of urinary tract infection, characterized by spontaneous gas formation in the urinary bladder. Patients with cystic fibrosis (CF) have several risk factors that predispose them to urolithiasis, such as hyperoxaluria, hypercalciuria, hyperuricosuria, and increased urinary saturation of calcium oxalate.2,3 Diabetes due to the pancreatic insufficiency common in CF may further increase risk of urinary infections and formation of renal stones.2,3 However, to our knowledge occurrence of emphysematous cystitis has not been reported in patients with cystic fibrosis. We describe a case of emphysematous cystitis and renal stones in a patient with cystic fibrosis.

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