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November 3, 2004

Androgen Suppression Plus Radiation Therapy for Prostate Cancer

JAMA. 2004;292(17):2084-2085. doi:10.1001/jama.292.17.2084-b

To the Editor: In the study by Dr D’Amico and colleagues1 an improvement in survival and freedom from salvage therapy was observed with androgen suppression therapy (AST) plus radiation therapy (RT). While there are patients who benefit from AST under certain conditions, what still remains unclear is which patients (intermediate- vs high-risk) should be treated with short-term (≤6 months) AST plus RT vs long-term (>2 years) AST plus RT, and whether any AST is necessary in the setting of RT dose escalation.

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