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November 17, 2004

Isoflavones and Postmenopausal Women

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(19):2338-2339. doi:10.1001/jama.292.19.2337-a

To the Editor: I am concerned that the study by Dr Kreijkamp-Kaspers et al1 may have failed to ensure adequate vitamin D intake and to control for serum 25-hydroxyvitamin D status among its participants. The data presented in Table 3 of the article indicate that vitamin D intake in the treatment group actually decreased from 4.27 μg (171 IU) to 3.54 μg (142 IU) during the study period. Vitamin D intake at this level would be insufficient to maintain minimum serum vitamin D levels and to sustain bone health, with a daily intake of 1000 IU suggested as the minimal dose to prevent osteoporosis.2 In addition, the city of Utrecht, from which their patient population was selected, is located in a region with a high incidence of hypovitaminosis D.24

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