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November 17, 2004

Proteomic Profiling and Intra-amniotic Infection

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(19):2339-2340. doi:10.1001/jama.292.19.2338-a

To the Editor: Dr Gravett et al1 studied 33 samples of human amniotic fluid in an attempt to relate biomarkers to intra-amniotic infection (IAI). Surface-enhanced laser desorption-ionization/time-of-flight (SELDI-TOF) mass spectrometry identified possible biomarker peaks in preterm intra-amniotic fluid in the 3- to 5-kDa and 11- to 12-kDa regions. The authors supported their conclusions using tryptic digests subject to liquid chromatography–tandem mass spectrometry analysis. They argued that calgranulin B and a fragment of insulinlike growth factor binding protein 1 (IGFBP-1) are biomarkers of IAI. Several aspects of this preliminary communication remain unclear.

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