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November 24, 2004

Erectile Dysfunction in Obese Men

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(20):2466-2467. doi:10.1001/jama.292.20.2467-a

To the Editor: Dr Esposito and colleagues1 report that caloric restriction and increased physical activity led to weight loss, a decrease in markers of inflammation, and improvement in erectile function in obese men with erectile dysfunction. The authors suggest that this improvement may relate to changes in endothelial function, an idea that is also addressed in the accompanying editorial by Dr Saigal.2 In the same issue of JAMA, Dr Morgentaler3 discusses the important interactions between testosterone and erectile function. Obesity is also associated with decreased levels of testosterone and free testosterone, and increased peripheral conversion of androgens to estrogen.4,5 Given this, it would be helpful to know if Esposito et al measured testosterone levels, and, if so, whether there was a change related to weight loss.

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