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December 1, 2004

Adolescents With Depression

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(21):2577-2579. doi:10.1001/jama.292.21.2577-b

To the Editor: While the TADS trial provides valuable data about a significant problem, we differ from the authors in their conclusion that treatment with fluoxetine should be made widely available, and that CBT in combination with fluoxetine should be “readily available as part of comprehensive treatment for depressed adolescents.”1 Because 2 of 3 outcome measures (Clinical Global Impressions [CGI] and Reynolds Adolescent Depression Scale [RADS]) show no significant difference between fluoxetine treatment alone and fluoxetine in combination with CBT, we do not see this study showing an advantage for the addition of CBT in all adolescents with MDD.

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