[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Citations 0
December 1, 2004

Adolescents With Depression

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(21):2577-2579. doi:10.1001/jama.292.21.2578-a

To the Editor: In interpreting the TADS results,1 the central issue is the benefit-to-risk ratio, which can be determined by considering the number needed to treat (NNT), the number needed to harm (NNH), and the number needed to prevent.2 In this study, a categorical positive response was achieved in 71.0% of participants treated with fluoxetine in combination with CBT; in 60.6% with fluoxetine alone; in 43.2% with CBT alone; and in 34.8% with placebo. Based on these outcomes, the NNT is 3.9 for fluoxetine alone compared with placebo and 3.7 for drug vs no drug. I believe that these represent low NNTs (high benefit) that are clinically meaningful.

First Page Preview View Large
First page PDF preview
First page PDF preview