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December 1, 2004

Adolescents With Depression

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(21):2577-2579. doi:10.1001/jama.292.21.2578-b

To the Editor: In their study, the TADS Team reported that the most effective treatment was fluoxetine in combination with CBT.1 Treatment with CBT alone was less effective than treatment with fluoxetine alone and not significantly more effective than treatment with pill placebo. The TADS Team was surprised by the 43% clinical response rate for CBT alone, which was lower than in some other studies,2,3 and posited that the lower response rate may have been due to greater severity, chronicity, and comorbidity in the TADS trial participants compared with previous trials.

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