Letters Section Editor: Robert M. Golub,
MD, Senior Editor.
To the Editor: In their study, the TADS Team
reported that the most effective treatment was fluoxetine in combination with
CBT.1 Treatment with CBT alone was less effective
than treatment with fluoxetine alone and not significantly more effective
than treatment with pill placebo. The TADS Team was surprised by the 43% clinical
response rate for CBT alone, which was lower than in some other studies,2,3 and posited that the lower response
rate may have been due to greater severity, chronicity, and comorbidity in
the TADS trial participants compared with previous trials.
Bridge JA, Brent DA. Adolescents With Depression. JAMA. 2004;292(21):2577-2579. doi:10.1001/jama.292.21.2578-b