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December 1, 2004

Vitamin K Deficiency and Hepatocellular Carcinoma

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2004;292(21):2580-2581. doi:10.1001/jama.292.21.2580-b

To the Editor: The study by Dr Habu and colleagues1 suggests that vitamin K2 (menaquinone) supplementation prevents hepatocellular carcinoma in women with viral cirrhosis of the liver. Supplementation would be expected to be more beneficial in patients who have a vitamin K deficiency at the onset of the study, but the vitamin K status of the patients was not reported.

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