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Medical News and Perspectives
December 15, 2004

Mitochondrial Defects May Play Role in the Metabolic Syndrome

JAMA. 2004;292(23):2823-2824. doi:10.1001/jama.292.23.2823

While the metabolic syndrome has been thrust into the spotlight because of the obesity epidemic, it is clear that the condition is not simply caused by lifestyle habits such as overeating and inactivity. Genetic components likely play a role, and scientists have now identified a potential genetic culprit for some individuals with the condition.


An estimated 47 million people in the United States have the metabolic syndrome, which is associated with the development of diabetes and heart disease. Factors characteristic of the syndrome include

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