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January 5, 2005

High-Dose Statins in Acute Coronary Syndromes

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;293(1):36-39. doi:10.1001/jama.293.1.36-a

To the Editor: The article by Dr de Lemos et al1 reporting the results of phase Z of the A to Z trial and the accompanying editorial by Dr Nissen2 provide important new information about event reduction by statins. Differences between conclusions of the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL)3 and the Pravastatin or Atorvastatin Evaluation and Infection Therapy (PROVE IT)4 trials may be due to differences in trial design.

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