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January 12, 2005

Clinical Trial Registration and the ICMJE

JAMA. 2005;293(2):157-158. doi:10.1001/jama.293.2.157-b

To the Editor: The International Committee of Medical Journal Editors (ICMJE)1 rightly decries selective reporting of trials with positive results. However, a contributing problem is publication bias toward positive results, which distorts the “base” of evidence-based medicine.24 The journal editors could help reverse publication bias by committing to publish trials with negative results as regular columns or as supplements. Creating such a forum would remove investigator reluctance to submit such work for publication, validate the importance of trials with negative results, and help to reclaim public trust.

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