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January 12, 2005

Clinical Trial Registration and the ICMJE—Reply

JAMA. 2005;293(2):157-158. doi:10.1001/jama.293.2.158-a

In Reply: Thank you to all who responded to the joint editorial published by the ICMJE. I respond only for myself to the 3 authors whose representative letters appear in this issue of JAMA.

Ms Dresser addresses the advantage of a comprehensive trial registry in raising public awareness that the purpose of clinical research is to advance knowledge, not to provide the best treatment for participants. I submit that the raised public awareness and the occasional successful treatment of patients who volunteer for such studies are both secondary but welcome outcomes of a clinical trial registry.

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