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January 12, 2005

Global Risk Score and Exercise Testing—Reply

JAMA. 2005;293(2):159-160. doi:10.1001/jama.293.2.160-a

In Reply: Dr Palatini raises the question of the prognostic value of the resting heart rate. When considered alone, an increase in resting heart rate was predictive of all-cause mortality (HR for each 10-beat increase, 1.24 [95% confidence interval {CI}, 1.09-1.41]; P = .001). This association persisted after adjustment for European SCORE (adjusted HR, 1.26 [95% CI, 1.11-1.44]; P<.001). However, the predictive power of the resting heart rate was markedly attenuated after also accounting for the exercise test findings (adjusted HR, 1.14 [95% CI, 0.99-1.32]; P = .06) while functional capacity in particular remained a strong predictor of death (adjusted HR, 2.77 [95% CI, 1.85-4.15]; P<.001).

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