To the Editor: The family with resistance to
thyroid hormone (RTH) described by Dr Anselmo and colleagues1 provides
a unique opportunity to examine the effects of excess maternal thyroxine on
the fetus. We believe that the conclusion that hormone overreplacement in
hypothyroidism should be avoided in pregnant women is premature based on the
data they provide.
Chang AY, Chamberlain-Shea H, Carr B. Fetal Loss Associated With Excess Thyroid Hormone Exposure. JAMA. 2005;293(2):160-161. doi:10.1001/jama.293.2.160-b