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Medical News and Perspectives
January 19, 2005

Down Syndrome Protein Deters Cancer

JAMA. 2005;293(3):284-285. doi:10.1001/jama.293.3.284

Although the detrimental effects of Down syndrome such as mental retardation and congenital heart defects are well known to clinicians, less familiar are apparent benefits seen in many patients with the condition, such as decreased incidences of diabetic retinopathies, atheromas, and some cancers (particularly solid tumors)—conditions linked to angiogenesis. Now, a new study offers a promising theory to explain this phenomenon and perhaps point the way to new antiangiogenic therapies (Minami et al. J Biol Chem. 2004;279:50537-50554).

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