Although the detrimental effects of Down syndrome such as mental retardation
and congenital heart defects are well known to clinicians, less familiar are
apparent benefits seen in many patients with the condition, such as decreased
incidences of diabetic retinopathies, atheromas, and some cancers (particularly
solid tumors)—conditions linked to angiogenesis. Now, a new study offers
a promising theory to explain this phenomenon and perhaps point the way to
new antiangiogenic therapies (Minami et al. J Biol Chem. 2004;279:50537-50554).
Hampton T. Down Syndrome Protein Deters Cancer. JAMA. 2005;293(3):284-285. doi:10.1001/jama.293.3.284