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January 26, 2005

Simple Principles of Clinical Trials Remain Powerful

Author Affiliations

Author Affiliations: Duke Clinical Research Institute, Durham, NC.

JAMA. 2005;293(4):489-491. doi:10.1001/jama.293.4.489

In this issue of JAMA, 2 articles from the Clinical Trial of Reviparin and Metabolic Modulation in Acute Myocardial Infarction Treatment Evaluation (CREATE) greatly enhance the knowledge base for the treatment of acute ST-segment elevation myocardial infarction (STEMI).1,2 Yet, as with all good clinical trials, this study raises new questions and perspectives that deserve further consideration.

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