Contempo Updates Section Editor: Sarah Ringold,
MD, Fishbein Fellow.
Author Affiliations: Center for Molecular Imaging
Research, Massachusetts General Hospital, Harvard Medical School, Charlestown
(Drs Jaffer and Weissleder); Cardiology Division, Department of Medicine,
Massachusetts General Hospital, Harvard Medical School, Boston (Dr Jaffer).
Molecular imaging is an emerging field that aims to integrate patient-specific
and disease-specific molecular information with traditional anatomical imaging
readouts. The information provided by this field may ultimately allow for
noninvasive or minimally invasive molecular diagnostic capabilities, better
clinical risk stratification, more optimal selection of disease therapy, and
improved assessment of treatment efficacy. In this update, we first provide
an overview of clinically relevant molecular imaging technologies and imaging
agents. Next, their applications to disease detection, drug discovery, and
biomedical research are discussed. To specifically demonstrate the potential
of molecular imaging, we highlight recent advances in clinical and preclinical
molecular imaging of cancer and atherosclerosis.
Jaffer FA, Weissleder R. Molecular Imaging in the Clinical Arena. JAMA. 2005;293(7):855-862. doi:10.1001/jama.293.7.855