JAMA 100 Years Ago Section Editor: Jennifer
Reiling, Assistant Editor.
It is not so very long since it was generally believed that the series
of events that occurred in a peripheral nerve after it had been divided were
fairly well understood and established. It was generally taught that the axis
cylinder in the peripheral part rapidly underwent degeneration throughout
its entire length, while the peripheral end, because it was still connected
with the nerve cells of which it formed a part, degenerated but little, as
far as the nearest node of Ranvier. Regeneration, it was believed, must come
entirely from the central portion, for here alone was the axis cylinder still
in continuity with its cell. All of the new-formed axis cylinders in the peripheral
portion of the injured nerve were believed to have been entirely derived from
the central portion, which pushed its way down along the old nerve sheaths
that were left after the degenerated peripheral fibers had been absorbed.
Continued investigations have failed to establish the accuracy of this comparatively
simple conception, and have tended rather to confuse the picture. Hence an
exhaustive review of the literature on this important subject, recently published
by Schütte,1 and the conclusions reached
therefrom, are of considerable interest.
REGENERATION OF PERIPHERAL NERVES.. JAMA. 2005;293(7):877. doi:10.1001/jama.293.7.877