Author Affiliations: Department of Internal
Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Osteoporotic fractures are a major health problem in Western society
and are associated with increased morbidity and mortality and substantial
economic costs.1 Because the number of fractures
will increase throughout the world as the population ages, prevention of fractures
is becoming increasingly important. Recently, studies have identified a new
and potentially modifiable risk factor for osteoporotic fracture—a mildly
elevated circulating homocysteine level.2,3 These
epidemiological studies showed that a relatively high homocysteine level predicts
a higher fracture risk but they did not establish a causal relationship. The
question remained whether the increase in fracture risk was due to homocysteine
itself, or to other covarying factors.
van Meurs JBJ, Uitterlinden AG. Homocysteine and Fracture Prevention. JAMA. 2005;293(9):1121-1122. doi:10.1001/jama.293.9.1121