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March 9, 2005

Antihypertensive Agents and Cardiovascular Events in Patients With Coronary Disease and Normal Blood Pressure—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;293(10):1187-1189. doi:10.1001/jama.293.10.1188-b

In Reply: Dr Aboyans and colleagues raise a number of salient issues regarding the CAMELOT study. With regard to selection bias, we did examine the demographic characteristics of patients in the IVUS substudy; their clinical characteristics were very similar to those enrolled in the main trial. With regard to comparisons with the REVERSAL trial,2 we were reluctant to make any statements regarding the relative effects of statins and antihypertensive agents on atherosclerosis progression, primarily because comparing 2 different trial populations is hazardous even when demographic characteristics are similar. In addition, treatment duration was 18 months in REVERSAL and 24 months in CAMELOT.

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