Letters Section Editor: Robert M. Golub,
MD, Senior Editor.
In Reply: Dr Aboyans and colleagues raise a
number of salient issues regarding the CAMELOT study. With regard to selection
bias, we did examine the demographic characteristics of patients in the IVUS
substudy; their clinical characteristics were very similar to those enrolled
in the main trial. With regard to comparisons with the REVERSAL trial,2 we were reluctant to make any statements regarding
the relative effects of statins and antihypertensive agents on atherosclerosis
progression, primarily because comparing 2 different trial populations is
hazardous even when demographic characteristics are similar. In addition,
treatment duration was 18 months in REVERSAL and 24 months in CAMELOT.
Nissen SE, For the CAMELOT Investigators . Antihypertensive Agents and Cardiovascular Events in Patients With Coronary Disease and Normal Blood Pressure—Reply. JAMA. 2005;293(10):1187-1189. doi:10.1001/jama.293.10.1188-b