Letters Section Editor: Robert M. Golub,
MD, Senior Editor.
In Reply: Dr Gonzalez-Feldman raises concerns
about interpretation of changes in HOMA-IR. The study by Haffner et al1 was cited to document the validity of HOMA-IR as a
measure of insulin resistance in large numbers of patients. HOMA-IR correlates
well with more complex testing such as the euglycemic clamp method (r2 = –0.88; P<.001) and the minimal model (r = 0.7; P<.001).2,3 A
review of this test in the context of large studies documents its validity.4
Bell DS, Bakris GL. Carvedilol, Metoprolol, and Insulin Resistance—Reply. JAMA. 2005;293(10):1190. doi:10.1001/jama.293.10.1190-b