Letters Section Editor: Robert M. Golub,
MD, Senior Editor.
To the Editor: Ribavirin has been used in combination
with interferon (IFN) alfa to treat chronic hepatitis C. This combination
therapy has been reported to be more effective than IFN monotherapy for eradicating
hepatitis C virus (HCV),1- 3 including
that occurring in patients with concomitant hemophilia.4,5 We
are unaware of previous reports of reduction in the use of clotting factors
in HCV-positive patients with hemophilia treated with ribavirin and IFN.
Honda T, Toyoda H, Hayashi K, Katano Y, Yano M, Nakano I, Yoshioka K, Goto H, Yamamoto K, Takamatsu J. Ribavirin and Use of Clotting Factors in Patients With Hemophilia and Chronic Hepatitis C. JAMA. 2005;293(10):1187-1192. doi:10.1001/jama.293.10.1190-c