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March 9, 2005

Ribavirin and Use of Clotting Factors in Patients With Hemophilia and Chronic Hepatitis C

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2005;293(10):1187-1192. doi:10.1001/jama.293.10.1190-c

To the Editor: Ribavirin has been used in combination with interferon (IFN) alfa to treat chronic hepatitis C. This combination therapy has been reported to be more effective than IFN monotherapy for eradicating hepatitis C virus (HCV),13 including that occurring in patients with concomitant hemophilia.4,5 We are unaware of previous reports of reduction in the use of clotting factors in HCV-positive patients with hemophilia treated with ribavirin and IFN.

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